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Adcetris


Producer: Takeda Pharma

contains

Adcetris is a means of immunotherapy (antibody).

Active substances

Brentuximab vedotin


Application

Adcetris is used to treat certain forms of lymphoma (non-Hodgkin's lymphoma and cutaneous T-cell lymphoma, most commonly located in the skin).

Only used in hospitals.


Dosage

Available as a powder for concentrate for solution for infusion, after reconstitution and dilution, into a vein.

  • Adults: Usually 1.8 mg per kg body weight (not more than 180 mg) every 3 weeks.

Note:

  • In case of malnourished kidneys or liver, the dose should be reduced.

possible side effects

Very common (over 10%)

Fever, Reactions and Discomfort during Infusion, Fatigue, Weight Loss

Diarrhea, Constipation, Nausea, Abdominal pain, Vomiting

Cough, Spiritlessness

Increased risk of infection due to lack of white blood cells

Joint pain, Muscle pain

Nervous inflammation, eg on the arms and legs

Skin rash, skin rash

Infections, respiratory infection

Common (1-10%)

Chills

Liver effect, Sponge in the mouth

pneumonia

Blood deficiency, increased tendency to bleeding due to decrease in platelets

Elevated blood sugar

Back pain

Nervous system disorders, Dizziness

Shingles, Hair loss

Uncommon (0.1-1%)

Inflammation of the pancreas

Destruction of the nerve around the nerve

Severe skin reaction, Severe skin reaction where the skin is destroyed

Anaphylactic shock - An acute severe allergic condition, Blood poisoning

Unknown

Virus infection in the brain

If the organism is unable to get rid of all the cells that Adcetris has broken, so-called tumor light can occur, which can lead to an abnormally high level of waste in the blood and possibly kidney failure. If side pain occurs or blood is present in the urine, it may be a sign of tumor light and in this case you should seek medical advice.



Pregnancy

Use only under certain conditions.
  • There is limited experience with the use of the agent for pregnant women. Should only be used in special cases after consultation with the specialist.

breastfeeding

Do not use this text. This text differs from the company's approved product information (product summary).

Traffic

No warning.

Blood donor

Do not drop. Donor must be declared by the donor village.

effect

  • Adcetris is a cell-inducing agent that is coupled to a carrier that leads the cell-killing agent to the cancer cells. Here, the cell-killing agent is released into the cancer cell, which prevents the cancer cell from dividing itself, after which it goes to the ground.
  • The half life in the blood (T?) is 4-6 days.

Pharmaceutical forms

Powder for concentrate for solution for infusion. 1 vial contains 50 mg brentuximab vedotin.


Special warnings

  • In case of a lack of white blood cells (tends to infect) or by nerve infection on eg arms and legs, the dose should be reduced.
  • If psychological or neurological side effects occur, for example in the form of confusion, balance problems, visual disturbances, memory or speech problems, it may be a sign of serious and possibly fatal brain inflammation and you should contact your doctor immediately.

Using other medicines

It is important to inform your doctor about all the medicines you are taking.
  • Concomitant use of bleomycin (cell killers) should be avoided due to increased risk of lung damage.
  • Certain fungicides (eg itraconazole) may increase the effect of Adcetris and increase the risk of infection.
  • Rifampicin (tuberculosis) may reduce the effect of Adcetris.

Grants, delivery, packages and prices

subsidiesextraditionDispensing form and strengthPackingPrice in kr.
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Apowder for concentrate for solution for infusion, opl.50 mg1 piece.30.848,10




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