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Adempas


Producer: Bayer

contains

Adempas is a medicine for high blood pressure in the lungs blood vessels.

Active substances

Riociguat


Application

Adempas is used in high blood pressure in the lungs or in the blood vessels of the lungs.

Must only be delivered from hospital.


Dosage

Available as tablets.

Adults

  • Initial dose: usually 1 mg 3 times a day for 2 weeks.
  • The dose is increased by 0.5 mg 3 times a day every 2 weeks to a maximum of 2.5 mg 3 times a day.
  • In case of severe blood pressure drops, high blood pressure below 95 mmHg or signs of low blood pressure, the dose should be reduced.
  • If you have not taken Adempas for 3 days or more, treatment should be resumed with 1 mg 3 times a day for 2 weeks and the dose increases every 2 weeks.

Note: Tablets should be taken consistently with or without food to avoid low blood pressure.


possible side effects

Very common (over 10%)

Diarrhea, Indigestion, Nausea, Vomiting

Liquid accumulation in, for example, arms and legs

Headache, dizziness

Common (1-10%)

Inflammation of the gastrointestinal mucosa, inflammation of the gastrointestinal tract, constipation, abdominal pain, acid reflux, difficulty in swallowing

Heartbeat, Low blood pressure, Nose bleeding, Blood rash, Stopped nose

Anemia

Uncommon (0.1-1%)

Bleeding in the lungs

In long-term studies, severe bleeding in the lungs has been observed.


Should not be used

Adempas should not be used for:

  • Very poor working liver
  • Very poor functioning kidneys
  • Systolic blood pressure (the "high" blood pressure) below 95 mmHg.

Pregnancy

Do not use.

Women of childbearing age should use safety precautions during treatment.


breastfeeding

Should not be used due to lack of knowledge. This text differs from the company's approved product information (product summary).

Traffic

No warning.

Blood donor

Do not drop. Donor must be declared by the donor village.

effect

Works by expanding the blood vessels in the lungs to reduce blood pressure.

The half life in the blood (T?) is approximately 12 hours.


Pharmaceutical forms

tablets. 1 tablet (film-coated) contains 0.5 mg, 1 mg, 1.5 mg, 2 mg or 2.5 mg riociguate.


Special warnings

The product should be used with caution when:

  • Older people over 65 years due to increased risk of low blood pressure
  • Badly functioning liver
  • Badly functioning kidneys
  • Low blood pressure
  • Certain cardiovascular diseases.
  • Smoking may reduce the effect of the drug and change in smoking conditions may require a change in dose.

Using other medicines

It is important to inform your doctor about all the medicines you are taking.
  • Adempas enhances the effects of nitrate preparations (anti-cardiac cramps), and concomitant use may cause severe blood pressure drop. The combination must be avoided.
  • Antipotentic agents (sildenafil, tadalafil, vardenafil) enhance the blood pressure lowering effect of Adempas and must not be taken at the same time.
  • Fungicides (voriconazole and itraconazole) and protease inhibitors (anti-HIV agents) increase the effect of Adempas and must not be taken at the same time.
  • Concomitant treatment with ciclosporin (agent for organ transplantation) and cell killers (erlotinib, gefitinib) should be performed with caution.
  • Acid neutralizers (antacids) should be taken at least two hours before or one hour after Adempas.
  • Bosentan (antihypertensive agent), anti-epileptic drugs (carbamazepine, phenobarbital, phenytoin) and perikon herbal medicines may reduce the effect of Adempas.

Grants, delivery, packages and prices

subsidiesextraditionDispensing form and strengthPackingPrice in kr.
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 0.5 mg42 pcs. (Blister)12.857,65
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 1 mg42 pcs. (Blister)12.857,65
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 1 mg84 pcs. (Blister)25.697,25
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 1.5 mg42 pcs. (Blister)12.857,65
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 1.5 mg84 pcs. (Blister)25.697,25
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 2 mg42 pcs. (Blister)12.857,65
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 2 mg84 pcs. (Blister)25.697,25
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 2.5 mg42 pcs. (Blister)12.857,65
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 2.5 mg84 pcs. (blister) (Abacus)26.372,85
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Afilm-coated tablets 2.5 mg84 pcs. (Blister)25.697,25


dyes

Iron oxides and iron hydroxides (E172)

Titanium dioxide (E171)




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