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Advagraf®


Producer: Astellas Pharma

contains

Advagraf® is a means of rejection of organs after transplantation.

Active substances

tacrolimus


Application

Advagraf® is used to prevent the body from repelling the new organ after liver or kidney transplantation.

Must only be delivered from hospital.


Dosage

Available as custody caps.

  • The dose is individual.

Note:

  • As far as possible, you should not switch between different drug forms (eg prolonged-release capsules and oral suspension) with tacrolimus. There is a risk that the funds will not have the same effect. If it is necessary to change, it must be done under close supervision by a specialist.
  • The capsules should be swallowed whole.
  • The capsules should be taken with a glass of water at least 1 hour before or 2-3 hours after a meal.

possible side effects

Very common (over 10%)

Diarrhea, Nausea

Hypertension

Diabetes, Too much potassium in the blood, Increased blood sugar

Headache, asthenia, insomnia

Impact of the kidneys

Common (1-10%)

Fever, Powerlessness, Reduced appetite, Weight gain

Inflammation of the gastrointestinal tract, Indigestion, Gut of the intestine, Liver effect, Abdominal pain, Mouth inflammation, Vomiting

Blood clots, Throat inflammation, Cardiac arrest, Coughing, Rapid pulse, Swelling due to fluid accumulation in the body, Stuffed nose, Liquid jointing in the lungs, Shortness of breath

Loss of blood, Increased white blood cell count, Increased risk of infection due to lack of white blood cells, Increased tendency to bleeding due to decrease in platelets

Too much fat in the blood, Too much cholesterol in the blood, Too much acid in the blood, Increased uric acid in the blood, Salt balance disturbance

Joint pain, Muscle cramps, Back pain, Pain in legs and legs

Anxiety, Consciousness, Depression, Confusion, Emotional instability, Hallucinations, Cramps, Nervous inflammation eg on the arms and legs, Dizziness, Change in the sensory of the skin

Acne, skin rash, skin rash, hair loss, increased sweating

Acute renal failure

Eye sensitivity, Visual disturbance, Tinnitus

Uncommon (0.1-1%)

Blood clot in the deep veins, cerebral hemorrhage, cardiac arrhythmia, cardiac arrest, cardiac failure, affect of ekg

Blood deficiency and increased risk of infection due to lack of white blood cells

Memory Disorders, Coming, Psychosis, Impact of the Brain, Talebesv?r

Skin inflammation, Hypersensitivity to sunlight

Simultaneous failure of two or more bodies

Upholstered urine production

Cataracts, Hearing loss

Rare (0.01-0.1%)

Acute breathing difficulties, fluid accumulation in the heart rate

Skin bleeding and mucous membranes

Severe skin reaction where the skin goes to the ground

Blindness

Very rare (less than 0.01%)

muscle weakness

Severe skin reaction

Unknown

Allergic reactions, anaphylactic shock - an acute severe allergic condition

In addition, treatment with the drug will lead to a slightly increased risk of developing cancer later in life.

A very severe reduction in the number of red blood cells has occurred (frequency unknown).


Should not be used

Should not be used in hypersensitivity to macrolide antibiotics (eg erythromycin).


Pregnancy

Use only under certain conditions.
  • There may be a slightly increased risk of congenital malformations. However, a necessary treatment should continue during pregnancy, as agreed with your doctor.

breastfeeding

Do not use this text. This text differs from the company's approved product information (product summary).

Traffic

No warning.

Blood donor

Do not drop. Donor must be declared by the donor village.

effect

  • Works by suppressing the body's natural immune system.
  • The half life in the blood (T?) is 6-21 hours.

Pharmaceutical forms

Depot capsules, hard. 1 prolonged-release capsule contains 0.5 mg, 1 mg, 3 mg or 5 mg tacrolimus.



Using other medicines

It is important to inform your doctor about all the medicines you are taking.
  • Erythromycin (antibiotic) increases the effect of Advagraf┬«.
  • Epilepsy drugs (phenobarbital and carbamazepine) and tuberculosis drugs (rifampicin and isoniazid) may reduce the effect of Advagraf┬«.
  • Advagraf┬« increases the effect of ciclosporin (other agent in organ transplantation) and the drugs should not be taken at the same time.
  • Advagraf┬« may reduce the effect of contraceptives. Concomitant treatment with amphotericin B (fungicide), antibiotics (aminoglycosides, sulfonamides and trimethoprim), melphalan (anticancer), antivirals (ganciclovir and aciclovir) and other organ transplants may cause kidney damage.

Grants, delivery, packages and prices

subsidiesextraditionDispensing form and strengthPackingPrice in kr.
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Ahard depot capsules0.5 mg50 pcs. (Blister)831,55
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Ahard depot capsules1 mg50 x 1 pcs. (Blister)1.269,55
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Ahard depot capsules3 mg50 pcs. (unit dose) (blister)3.995,10
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Ahard depot capsules5 mg50 pcs. (Blister)6.231,45


dyes

Iron oxides and iron hydroxides (E172)

Titanium dioxide (E171)




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