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Afinitor


Producer: Novartis

contains

Afinitor is a medicine for immunotherapy (enzyme inhibitors).

Active substances

Everolimus


Application

Afinitor is used to treat

  • advanced forms of cancer in the kidney
  • certain types of breast cancer in women after menopause
  • scattered cancerous nodules that originate from the stomach, intestines, lungs or pancreas, and which can not be operated away.

Must only be delivered from hospital.


Dosage

Available as tablets.

  • Adults. Usually 10 mg once a day.

Note:

The tablets should be swallowed whole and taken at the same time each day. They should always be taken either with a meal or not with a meal.


possible side effects

Very common (over 10%)

Loss of appetite, fatigue, weight loss

Diarrhea, Nausea, Mouth inflammation, Taste disturbances

Cough, Pneumonia, Nose bleeding, Fluid retention in eg arms and legs

Anemia

Too much cholesterol in the blood, Increased blood sugar

Headache

Skin rash, skin rash

infections

Common (1-10%)

Fever

Liver affect, abdominal pain, dry mouth, vomiting, difficulty in swallowing

Elevated blood pressure, shortness of breath

Bleeding, Increased risk of infection due to lack of white blood cells, Increased tendency to bleeding due to decrease in platelets

Diabetes, too little calcium in the blood, too little potassium in the blood, too much fat in the blood, fluid shortage

Joint pain

Insomnia

Acne, severe skin reaction, severe rash and sensory disorder of hands and feet, inflammation of the mucous membranes, nail changes, hair loss, redness, dry skin

Increased creatinine in the blood, menstrual disturbances, kidney failure, urine urine

Raised eyelid

Uncommon (0.1-1%)

Blood clot in the deep veins, Blood clot in the lungs, Heart failure, Blood clotting

S?rhelingsproblemer

Allergic reactions

Undo menstruation

conjunctivitis

Rare (0.01-0.1%)

breathing difficulties

Allergic swelling of the face as well as the oral cavity and larynx


Should not be used

Should not be used in allergy to certain cell killers.


Pregnancy

Use only under certain conditions. This text differs from the company's approved product information (product summary). May be used only under certain conditions. This text differs from the company's approved product information (product summary).

breastfeeding

Should not be used due to lack of knowledge.

Traffic

No warning.

Blood donor

Do not drop. Donor must be declared by the donor village.

effect

  • By inhibiting a particular type of enzyme,protein kinase, which increases the growth of the cancer cells.
  • The half life in the blood (T?) is approximately 30 hours.

Pharmaceutical forms

Tablets. 1 tablet contains 2.5 mg, 5 mg or 10 mg everolimus.


Special warnings

  • Caution in hepatic impairment.
  • Should not be used if you have an infection such as pneumonia.
  • Vaccination with vaccines containing live but attenuated viruses should be avoided.
  • Grapefruit juice can increase the effect of Afinitor.

Using other medicines

It is important to inform your doctor about all the medicines you are taking.
  • Certain antibiotics (eg clarithromycin and erythromycin), certain cardiovascular and cardiac disorders (eg verapamil), certain anti-rejection organs (eg ciclosporin), certain anti-HIV and itraconazole (fungicide) agents may increase the effect of Afinitor.
  • Certain other antibiotics (eg rifampicin), adrenal gland hormone, certain anti-epileptic drugs (carbamazepine, phenobarbital and phenytoin) may reduce the effect of Afinitor.
  • Herbal remedies can change the effect of Afinitor.
  • Afinitor may increase the effect of pimozide (anticonvulsant) and ergotamine (migraine).
  • Concomitant use of ACE inhibitors (antihypertensive agents) may increase the risk of allergic swelling in the face, oral cavity and larynx.

Grants, delivery, packages and prices

subsidiesextraditionDispensing form and strengthPackingPrice in kr.
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Atablets 2.5 mg30 pcs. (Blister)11.361,15
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Atablets5 mg30 pcs. (Blister)23.275,00
May only be delivered to hospitals. Delivered according to the provisions for drugs in delivery group Atablets 10 mg30 pcs. (Blister)31.041,85




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