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Amitriptylin "DAK"


Producer: Takeda Pharma

contains

Amitriptyline "DAK" is a tricyclic antidepressant.

Active substances

amitriptyline


Application

Amitriptyline "DAK" is used for:

  • Depression.
  • Neuropathic pain.
  • Preventing chronic stress headache.
  • Prevention of migraine.
  • Certain cases of involuntary nightly urination in children over 6 years of age.

Dosage

Available as tablets.

tablets

Depression

  • Adults. Initial dose 25 mg twice a day, possibly increasing by 25 mg every 2 days to 150 mg per day divided into 1-2 doses.
  • Older people over 65 years of age and cardiovascular disease. Initial dose 10 mg twice a day, gradually increasing to 100-150 mg per day divided into 1-2 doses.
  • Note: No experience regarding children and adolescents under 18 years of age.

Neuropathic pain, chronic tension headache, migraine

  • Adults. Initial dose 10-25 mg a day in the evening, possibly increasing by 10-25 mg each 3-7. day. Usual maintenance dose 25-75 mg a day in the evening. Caution at doses above 100 mg per day. Single doses above 75 mg are not recommended.
  • Elderly over 65 years and patients with cardiovascular disease. Same dosage as in adults but initial dose at the low end of the interval and caution at doses above 75 mg per day is recommended.
  • Note: No experience regarding children and adolescents under 18 years of age.

Inadvertent nightly urination

  • Children 6-10 years. 10-20 mg a day.
  • Children over 11 years. 25-50 mg a day.
  • The dose is taken 1-1? hours before bedtime.
  • Dose search should be gradual.
  • Duration of treatment usually no more than 3 months. If you need longer treatment, you should be evaluated by your doctor every 3 months.
  • Note: No experience regarding children under 6 years old.

Note:

  • At the end of treatment, the dose should be gradually reduced.

possible side effects

Many of the side effects usually occur only at the beginning of treatment.

Very common (over 10%)

Weight gain

Constipation, Nausea, Dry mouth

Blood pressure drop when you get up, fast pulse, stuffed nose

Aggressiveness, Drowsiness, Headache, Rupture, Drowsiness, Dizziness, Speech

Increased sweating

Blurred vision

Common (1-10%)

Fatigue, thirsty

taste changes

Disturbances in the pulse between the central and central chambers of the heart, Cardiac arrhythmias, Impact of eczema (including prolonged QT interval *)

Too little sodium in the blood

Difficulty in controlling arms and legs, Confusion, Concentration difficulties, Unrest and restlessness, Change in the sensory of the skin

Reduced Sexual Illness, Travel Issues, Irrigation Disorders

Enlarged pupils

Uncommon (0.1-1%)

Swelling of the tongue, Liver effect

Elevated blood pressure, worsening heart failure, circuit break

Anxiety, cramps, slightly increased mood, ways

Liquid accumulation on the face

Lack of urination

Increased pressure in the eye, Tinnitus

Rare (0.01-0.1%)

tarmslyng

Influence of bone marrow production of blood cells, Increased risk of infection due to lack of white blood cells, Increased tendency to bleeding due to decrease in platelets

Development of breasts in men

Delirium - a state of confusion and influence on visual and hearing impairment (in the elderly), hallucinations (in schizophrenia), suicidal thoughts or behaviors

Hair loss, Hypersensitivity to sunlight

Very rare (less than 0.01%)

Heartbone, Cardiovascular Disease

Motor disorder, Nerve inflammation

Allergic pneumonia

Acute green throat

Unknown

Elevated temperature

hepatitis

Increased or low blood sugar

Side effects from the musculoskeletal system, psychosis

* Prolonged QT interval is a particular type of heart rhythm disorder, which in some cases can lead to sudden death.

  • Certain side effects, eg drowsiness, can be difficult to distinguish from the symptoms of depression.
  • Most side effects are seen more often in the elderly.
  • In patients over 50 years, an increased incidence of fractures has been observed in treatment with tricyclic antidepressants.

Should not be used

  • Heart failure in the first months after single blood clot in the heartbeat drug is not used.
  • By very poor working liver.

Pregnancy

Can be used if necessary.

Experience has shown that many pregnant women have been treated without a fetus injury. After childbirth, the child may feel irritable with crying, shaking and difficulty in dying and sleeping.


breastfeeding

Can be used if necessary.

Traffic

No warning.

Blood donor

Do not drop. 4 weeks quarantine after end of treatment.

effect

Works by increasing the amount of signal substances, including noradrenaline and serotoninwhich is important for the pulse transmission in the brain. The regulation of these pulses seems to play some role in the development of depression, but the exact mechanism of action is not known. The pain relieving effect of the drug is independent of the effect on depression and is probably due, inter alia, to affecting neurotransmitters.

The cause of the effect of involuntary nightly urination is not fully known. The full effect against depression can be expected after 2-6 weeks of treatment, while the effect on pain is usually seen after 2-4 weeks.

Amitriptyline is converted into the body into the drug nortriptyline, which has similar effect. The half-life in the blood (T?) is 9-46 hours for amitriptyline and 18-95 hours for nortriptyline.


Pharmaceutical forms

Tablets. 1 tablet (film-coated) contains 10 mg, 25 mg or 50 mg of amitriptyline hydrochloride.


Special warnings

  • Possible increased risk of suicidal ideation or suicide behavior at the start of treatment, especially in young people under 25. In the first weeks of treatment and changes in dose, attention should be paid to indications of possible suicidal ideation or suicide attempts at all - especially in symptoms of anxiety or if there have been cases of suicidal behavior in the past.
  • Use with caution in heart disease and in untreated schizophrenia as symptoms may deteriorate.
  • The epilepsy attacks increase.
  • Alcohol enhances the sedative effect of the drug.
  • The drug should be used with caution in case of increased pressure in the eye, green sting, lack of urination, thyroid gland, poor functioning of the liver, and if you have had a history of depression / hypomania
  • If you suffer from diabetes, it may be necessary to adjust the treatment for diabetes
  • Due to the increased risk of gaps in the teeth, regular dental control is recommended.
  • The drug should be used with caution if there is an increased risk of developing prolonged QT interval - a particular type of rhythm disturbance in the heart. For example, too little potassium in the blood, slow heart rate, various heart conditions, concomitant use of diuretics, and if you are a woman or over 65 years of age.
  • Caution in treating the elderly, eg. due to increased risk of sudden drop in blood pressure when getting up.
  • If you experience symptoms of cardiac arrhythmias (eg palpitation, dizziness, fainting), consult your doctor.
  • At the end of treatment, the dose should be reduced gradually (usually over at least 4 weeks). In case of sudden cessation, there is a risk of ending symptoms such as dizziness, movement disturbances, sleep disturbances, difficulty concentrating and flu-like symptoms.

Using other medicines

It is important to inform your doctor about all the medicines you are taking.
  • Antibiotics, certain SSRIs against depression, terbinafine (fungicide) and antihistamines may increase the effect of Amitriptylin "DAK".
  • Phenobarbital and certain epilepsy agents may reduce the effect of Amitriptylin "DAK".
  • It may be necessary to adjust the dosage of both agents by concomitant use of anti-psychosocial agents and certain anti-depressant agents (tricyclic antidepressants).
  • Valproate (antidiabetic medicine) may increase the effect.
  • Herbal remedies may reduce the effect.
  • Amitriptyline "DAK" may enhance the effect of sleepers.
  • Amitriptyline "DAK" may reduce the effect of clonidine (migraine).
  • Concomitant treatment with levodopa (anti-Parkinson's disease) may lead to high blood pressure.
  • Amitriptylin "DAK" must not be taken concomitantly with MAO inhibitors (anti-depressant, Parkinson's disease or infections) or have been treated with isocarboxazide (an MAOI) within the last 14 days.
  • Concomitant use of other anti-depressant agents (eg SSRIs, SNRIs and lithium) may cause serious side effects.
  • Concomitant use of dextromethorphan (anti-cough) may lead to an accumulation of dextromethorphan in the body.
  • Co-administration with fluvoxamine (another antidepressant) should be avoided as the effect of Amitriptylin "DAK" may be enhanced.
  • When co-administered with phenytoin (anti-epileptic and cardiac arrhythmias), there is an increased risk of phenytoin poisoning.
  • Caution with concomitant use of agents that may lead to prolonged QT interval - a particular form of heart rhythm disturbances. This applies, inter alia, to certain remedies for heart rhythm disorders, certain antipsychotic drugs, and more antibiotics and antidepressants.

Grants, delivery, packages and prices

subsidiesextraditionDispensing form and strengthPackingPrice in kr.

Amitriptylin

May only be delivered once after the same prescription unless the recipient has stated on the prescription, how many times and with what time intervals additional extradition must take placefilm-coated tablets10 mg100 pieces.45,55

Amitriptylin

May only be delivered once after the same prescription unless the recipient has stated on the prescription, how many times and with what time intervals additional extradition must take placefilm-coated tablets 25 mg100 pieces.58,75

Amitriptylin

May only be delivered once after the same prescription unless the recipient has stated on the prescription, how many times and with what time intervals additional extradition must take placefilm-coated tablets 50 mg100 pieces.86,50


dyes

Titanium dioxide (E171)


substitution

film-coated tablets 10 mg

Saroten Lundbeck Amitriptyline

Amitriptyline "Abcur" Abcur Amitriptyline

film-coated tablets 25 mg

Saroten Lundbeck Amitriptyline

Amitriptyline "Abcur" Abcur Amitriptyline



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