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Donepezil "Aurobindo"


Producer: Orion Pharma

contains

Donepezil "Aurobindo" is a medicine for the treatment of dementia.

Active substances

Donepezil


Application

Donepezil "Aurobindo" is used to treat the symptoms of dementia.


Dosage

Available as tablets.

Adults. The starting dose. Usually 5 mg once a day. After at least 1 month of treatment, the dose may be increased to 10 mg once a day.

Note:

Due. The risk of diarrhea is recommended that fragile patients take the drug in the morning at the start of treatment. Gastrointestinal effects usually fade after a few days and the medication can then be taken at the time that best suits the patient. Some side effects may, if they occur, be counteracted by taking a dose in the morning (increased dream activity) or in the evening (dizziness, nausea).


possible side effects

Very common (over 10%)

Diarrhea, Nausea

Headache

Common (1-10%)

Impaired appetite, Pain, Fatigue

vomiting

Hay fever

muscle cramps

Aggressiveness, Fainting, Hallucinations, Dizziness, Insomnia, Abnormal Dreams, Unrest and Restlessness

Skin rash, skin rash

Involuntary urination

Uncommon (0.1-1%)

Bleeding in the gastrointestinal tract

Slow pulse

Seizures

Rare (0.01-0.1%)

Badly functioning liver

Disturbances in the pulse between the head and the chambers of the heart

Side effects from the musculoskeletal system

Very rare (less than 0.01%)

Muscle tissue degradation *

Malignant neuroleptic syndrome - severe condition with fever and awareness raising **

* Most commonly seen at the start of treatment or by increasing the dose.

** In very rare cases - especially when combined with anti-psychosis drugs - it is seen so-called malignant neuroleptic syndrome. A severe condition with fever, muscle stiffness, impaired vigilance and sweating that require immediate medical attention.



Pregnancy

Not applicable.

breastfeeding

Not applicable.

Traffic

No warning.

Blood donor

Do not drop. Donor must be declared by the donor village.

effect

Works by increasing the amount of signalacetylcholine in the brain. This shows an improvement in the patient's daily function, but the treatment does not affect the progress of the disease. The half life in the blood (T?) is approximately 70 hours.


Pharmaceutical forms

Tablets. 1 tablet (film-coated) contains 5 mg or 10 mg donepezil hydrochloride.


Special warnings

  • Treatment should, as a general rule, only be initiated if the patient has a relative or caregiver who can help handle the treatment on a daily basis.
  • The drug should be used with cautionary ulcers, asthma or other pulmonary diseases, epilepsy, urinary incontinence and certain cardiac arrhythmia disorders.
  • There is no experience with the agent for very poorly functioning liver.
  • The weight should be followed as treatment can increase the risk of weight loss.
  • The drug should be used with caution if there is an increased risk of developing prolonged QT interval - a particular type of rhythm disturbance in the heart. For example, too little potassium in the blood, slow heart rate, various heart conditions, concurrent use of diuretics, and if you are a woman.

Using other medicines

It is important to inform your doctor about all the medicines you are taking.
  • A number of agents (including certain antifungal agents, certain antibiotics and certain anti-HIV agents) may increase the effect of Donepezil "Aurobindo".
  • Rifampicin (tuberculosis) and epilepsy agents (phenytoin and carbamazepine) may reduce the effect of Donepezil "Aurobindo".
  • Caution with concomitant use of agents that may lead to prolonged QT interval - a particular form of heart rhythm disturbances. This applies, inter alia, to certain remedies for heart rhythm disorders, certain antipsychotic drugs, and more antibiotics and antidepressants.

Grants, delivery, packages and prices

subsidiesextraditionDispensing form and strengthPackingPrice in kr.

Donepezil

May only be delivered once after the same recipe, unless the delivery takes place in several smaller portions at a timefilm-coated tablets5 mg28 pcs. (Blister)37,05

Donepezil

May only be delivered once after the same recipe, unless the delivery takes place in several smaller portions at a timefilm-coated tablets5 mg250 pcs.85,85

Donepezil

May only be delivered once after the same recipe, unless the delivery takes place in several smaller portions at a timefilm-coated tablets10 mg98 pcs. (Blister)64,15

Donepezil

May only be delivered once after the same recipe, unless the delivery takes place in several smaller portions at a timefilm-coated tablets10 mg250 pcs.109,55


dyes

Iron oxides and iron hydroxides (E172)

Titanium dioxide (E171)


substitution

film-coated tablets 5 mg

AriceptPfizer Donepezil

Donepezil "Sandoz" Sandoz Donepezil

Donepezil "Krka" KRKA Donepezil

Donepezil hydrochloride "Accord" Accord Donepezil

Donepezil "Stada" STADA Nordic Donepezil

Donepezil "Jubilant" Jubilant Donepezil

film-coated tablets 10 mg

AriceptPfizer Donepezil

Donepezil "Sandoz" Sandoz Donepezil

Donepezil "Krka" KRKA Donepezil

Donepezil hydrochloride "Accord" Accord Donepezil

Donepezil "Stada" STADA Nordic Donepezil

Donepezil "Jubilant" Jubilant Donepezil


Donepezil

FAQ - 💬

❓ What is donepezil used to treat?

👉 Donepezil is a medicine that helps with some types of dementia. It does not cure dementia. However, it treats some of the symptoms of Alzheimer's disease, Parkinson's disease or dementia with Lewy bodies. It can also help with "mixed dementia".

❓ What are the side effects of donepezil?

👉 Donepezil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • diarrhea.
  • loss of appetite.
  • weight loss.
  • frequent urination.
  • difficulty controlling urination.
  • muscle cramps.

❓ What is donepezil 5 mg used for?

👉 Donepezil is used to treat dementia (memory loss and mental changes) associated with mild, moderate, or severe Alzheimer's disease. Donepezil will not cure Alzheimer's disease, and it will not stop the disease from getting worse. However, it can improve thinking ability in some patients.

❓ Is donepezil effective for treating Alzheimer's disease?

👉 Donepezil is more effective than placebo and is well tolerated in improving the major symptoms of this disease....

Outcome measureEvidenceImplications
Economic evidence
Cost effectiveness in Alzheimer's disease patientsSomeDonepezil may be cost effective, especially when unpaid caregiver costs are considered

❓ What are the contraindications of donepezil?

👉 Who should not take Donepezil HCL?

  • low amount of magnesium in the blood.
  • low amount of potassium in the blood.
  • neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion.
  • a heart attack.
  • heart attack within the last 30 days.
  • atrioventricular block, a type of slow heart rhythm disorder.

❓ How long can a person take donepezil?

👉 Donepezil (5 and 10 mg) is an agent with a simple once-daily dosage schedule which improves cognition and global clinical function in the short (up to 24 weeks) and long term (up to about 1 year) in patients with mild to moderate Alzheimer's disease.

❓ Is donepezil a high risk medication?

👉 The American Geriatrics Society's Beer's list recognizes donepezil as a high-risk medication in older adults due to increased rates of orthostatic hypotension and bradycardia within this population.

❓ How long can you stay on donepezil?

👉 Donepezil (5 and 10 mg) is an agent with a simple once-daily dosage schedule which improves cognition and global clinical function in the short (up to 24 weeks) and long term (up to about 1 year) in patients with mild to moderate Alzheimer's disease.

❓ What happens if you stop donepezil?

👉 Terminating treatment, especially abruptly, is not without consequences for the patient. It has been reported that intense hallucinations can occur after sudden donepezil withdrawal [2]. One published study has suggested that discontinuation of treatment with donepezil may bring withdrawal symptoms [3].

❓ Can you stop donepezil suddenly?

👉 Terminating treatment, especially abruptly, is not without consequences for the patient. It has been reported that intense hallucinations can occur after sudden donepezil withdrawal [2]. One published study has suggested that discontinuation of treatment with donepezil may bring withdrawal symptoms [3].

❓ What happens if you stop taking donepezil?

👉 Terminating treatment, especially abruptly, is not without consequences for the patient. It has been reported that intense hallucinations can occur after sudden donepezil withdrawal [2]. One published study has suggested that discontinuation of treatment with donepezil may bring withdrawal symptoms [3].


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